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In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum / 生物医学与环境科学(英文)
Article in En | WPRIM | ID: wpr-229674
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.</p><p><b>METHOD</b>Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.</p><p><b>RESULTS</b>DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.</p><p><b>CONCLUSION</b>Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Pharmacology / Plasmodium falciparum / Umbelliferones / Pharmacokinetics / Chemistry / Antimalarials Limits: Animals Language: En Journal: Biomedical and Environmental Sciences Year: 2006 Type: Article
Full text: 1 Index: WPRIM Main subject: Pharmacology / Plasmodium falciparum / Umbelliferones / Pharmacokinetics / Chemistry / Antimalarials Limits: Animals Language: En Journal: Biomedical and Environmental Sciences Year: 2006 Type: Article