In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 367-370, 2006.
Article
in En
| WPRIM
| ID: wpr-229674
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.</p><p><b>METHOD</b>Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.</p><p><b>RESULTS</b>DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.</p><p><b>CONCLUSION</b>Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Plasmodium falciparum
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Umbelliferones
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Pharmacokinetics
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Chemistry
/
Antimalarials
Limits:
Animals
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2006
Type:
Article