Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in ethnic minority from Guizhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 589-591, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-229863
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the frequencies of GSTM1, GSTT1 and GSTP1 polymorphisms in Dong, Yi and Yao ethnic groups from Guizhou.</p><p><b>METHODS</b>In 321 volunteers who were population-based, GSTM1 and GSTT1 polymorphisms were analyzed by a multiplex-PCR procedure, whereas GSTP1 polymorphism was analyzed by PCR-RFLP method.</p><p><b>RESULTS</b>Null genotype for GSTM1 and GSTT1 was 59.6%-71.2% and 39.4%-72.5%, respectively. The genotypic distribution of GSTP1 was 63.3%-75% for AA, 23.2%-35.8% for AG, 0-1.9% for GG, whereas the allelic frequencies were 81.2%-86.6% for the A allele, and 13.4%-18.8% for the G allele.</p><p><b>CONCLUSION</b>There is a significant relationship between GSTT1 frequencies and ethnic populations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Ethnicity
/
China
/
Asian People
/
Glutathione S-Transferase pi
/
Ethnology
/
Gene Frequency
/
Genetics
/
Genotype
/
Glutathione Transferase
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2007
Type:
Article
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