Study on T13254C polymorphism of the platelet membrane glycoprotein VI in Chinese Han population / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 140-143, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-229882
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the T13254C polymorphism frequency in GPVI gene among Chinese Han population and its relevance to the arterial thrombotic diseases.</p><p><b>METHODS</b>The enrolled population in this study consisted of 314 healthy subjects and 274 patients with myocardial or cerebral infarctions. GPVI T13254C genotypes were determined by PCR amplification of a 355 bp fragment encompassing exon 5 of GPVI gene, followed by Msp I digestion of the product. The digested products were analyzed in 15% polyacrylamide gel electrophoresis (PAGE).</p><p><b>RESULTS</b>The frequencies of the T allele and C allele in the T13254C polymorphism were 0.9809 and 0.0191, respectively, with a frequency of heterozygous of 0.0319, which were significantly different from those reported in western population (P < 0.01). As compared with controls, no significant difference in T13254C genotype distribution was found in the arterial thrombotic diseases group.</p><p><b>CONCLUSION</b>The GPVI T13254C polymorphism appears in a low frequency in Chinese Han population. No relationship is found between T13254C polymorphism and the risk for thrombotic diseases.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Molecular Sequence Data
/
Base Sequence
/
Platelet Membrane Glycoproteins
/
China
/
Brain Infarction
/
Polymorphism, Single Nucleotide
/
Asian People
/
Alleles
/
Ethnology
/
Gene Frequency
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2005
Type:
Article
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