Liver X receptor: crucial mediator in lipid and carbohydrate metabolism / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 430-435, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-229959
ABSTRACT
Liver X receptors (LXRs) are members of the nuclear receptor superfamily and are activated by oxysterols and intermediates in the cholesterol synthetic pathway. The pivotal role of LXRs in the metabolic conversion of cholesterol to bile acids has been well established. Furthermore, insulin induces LXRa in hepatocytes, resulting in the suppression of key enzymes in gluconeogenesis, including phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, and fructose-1, 6-bisphosphatase (FBPase). LXRs also play an important role in fatty acid metabolism by activating the sterol regulatory element-bing protein 1c gene (SREBP1c). This articles reviews the molecular mechanisms by which LXRs act to influence the lipid and carbohydrate metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Carbohydrate Metabolism
/
Lipid Metabolism
/
Orphan Nuclear Receptors
/
Liver X Receptors
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS