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Clinical characteristics of 51 patients with mycosis fungoides / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 174-180, 2007.
Article in Chinese | WPRIM | ID: wpr-230009
ABSTRACT
<p><b>OBJECTIVE</b>To update the clinical characteristics of mycosis fungoides in Chinese patients.</p><p><b>METHOD</b>We retrospectively analyzed the clinical data of 51 patients (29 men and 22 women) with mycosis fungoides in PUMC hospital from 1984 to 2006, to determine the ages at diagnosis, clinicopathologic characteristics of skin lesions, systemic manifestation, misdiagnosis and treatment of these patients.</p><p><b>RESULTS</b>The mean age was (44.24 +/- 2.05) years at the diagnosis. Most patients were characterized by the typical evolution of patches, plaques and tumors, with some variations and subtypes. Clinical manifestations included generalized lesions (68.6%) and itchy (70.6%). Epidermotropism (68.6%) and Pautrier's microabscesses (52.9%) were common histopathologic features. The positive rate of T-cell receptor gene rearrangement was 81.3%, and was independent of the histological features. Previous misdiagnosis rate was 64.7%. Skin-targeted therapies and biologic therapies were effective approaches to relieve the skin rash at early stage, and combined chemotherapy was typically applied in more advanced cases.</p><p><b>CONCLUSION</b>Mycosis fungoides has various clinical characteristics and careful differential diagnosis should be made in clinical practice.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Skin Neoplasms / Receptors, Antigen, T-Cell / Gene Rearrangement / Retrospective Studies / Mycosis Fungoides / Diagnosis / Diagnostic Errors / Genetics Type of study: Diagnostic study / Observational study Limits: Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Skin Neoplasms / Receptors, Antigen, T-Cell / Gene Rearrangement / Retrospective Studies / Mycosis Fungoides / Diagnosis / Diagnostic Errors / Genetics Type of study: Diagnostic study / Observational study Limits: Female / Humans / Male Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2007 Type: Article