Relationship between hematopoietic development and endothelial cells (hemangioblast or hemogenic endothelium)--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 198-201, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-230301
ABSTRACT
Developmental programs of blood and endothelium are closely correlated and remarkably conserved among species. To categorize the ontogeny relationship between hematopoietic and endothelial lineages, two putative models are presented here. In the yolk sac, hematopoietic and endothelial cells are more likely derived from a common precursor--the hemangioblast. By comparison, the hemogenic endothelium is proposed to characterize the generation of hematopoietic stem cells from mature endothelium in the P-Sp/AGM region. Furthermore, couples of molecules, including Scl, Flk-1 and Runx-1, are involved in formation and subsequent differentiation of the hemangioblast or hemogenic endothelium during embryonic hematopoiesis. In this article, the development of primitive and definitive hematopoiesis, two models associated with development of hematopoietic and vascular endothelial cells as well as molecules associated with development of hematopoietic and endotheliate cells were summaried.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Yolk Sac
/
Endothelium, Vascular
/
Hematopoiesis
/
Hematopoietic System
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Type:
Article
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