Clinical analysis of triple marker screening test for fetal Down syndrome in midtrimester of pregnancy-Low sensitivity of triple marker screening test / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1914-1918, 1999.
Article
in Korean
| WPRIM
| ID: wpr-23055
ABSTRACT
OBJECTIVE:
To assess the reliability of triple marker screening test in midtrimester pregnancy for fetal Down syndrome.METHODS:
From October 1, 1996 to May 31, 1998 at Nowon Eulji Hospital, 3700 Pregnant women underwent serum tiple marker screening for Down syndrome during 15-20weeks of gestational age. The results of serum triple marker screenig tests for Down syndrome and the outcomes of pregnancies were retrospectively assesed.RESULTS:
Sixty seven of 3700 cases(1.81%) were positive in screening test, and 3633(98.18%) cases were negative. Among 67 cases of positive screening test, 1 case(1.49%) was diagnosed as Down syndrome. Among 3633 cases of negative screening test, 4 cases(0.1%) were diagnosed as chromosomal abnormalies postnatally. Two of these 4 cases of chromosomal abnormalies were Down syndrome.CONCLUSION:
With this results, sensitivity of triple marker screeing test for Down syndrome is very low as 33.3%. In order to increase the sensitivity, some compensatory adjustment is required in triple marker screening test.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Trimester, Second
/
Pregnancy Outcome
/
Mass Screening
/
Retrospective Studies
/
Gestational Age
/
Down Syndrome
/
Equidae
/
Pregnant Women
Type of study:
Diagnostic study
/
Observational study
/
Screening study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS