An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 431-436, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-230574
ABSTRACT
<p><b>OBJECTIVE</b>To assess the economic evaluation of short- and long-term antiviral treatments of HBeAg-positive chronic hepatitis B from the perspective of the Chinese health care system.</p><p><b>METHODS</b>A 10-health state Markov model was developed to estimate long-term cost and effectiveness of different treatments of HBeAg-positive CHB. Incremental cost-effectiveness analysis was then carried out.</p><p><b>RESULTS</b>In comparison with no antiviral treatment, lamivudine administered for 1-year was a highly cost-effective short-course treatment for HBeAg-positive CHB. However, of the treatments evaluated, lamivudine plus adefovir as a rescue medication or adefovir plus lamivudine as a rescue medication administered for 5 years resulted in a more sustained decrease in the rate of disease progression. In comparison with 1 year lamivudine treatment, the incremental cost per Quality Adjusted Life Year (QALY) for treatment with lamivudine plus adefovir or adefovir plus lamivudine as a rescue medication for 5 years was CNY 25 115 and 35 577 respectively, which was 55.2% and 36.5% lower than the estimated international threshold value for China.</p><p><b>CONCLUSION</b>In comparison with no antiviral treatment, lamivudine administered for 1-year is a highly cost-effective short-course treatment. Longer duration antiviral treatments, lamivudine plus adefovir or adefovir plus lamivudine as a rescue medication are both cost-effective strategies, resulting in a more sustained decrease in the rate of disease progression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Blood
/
Adenine
/
Treatment Outcome
/
Cost-Benefit Analysis
/
Quality-Adjusted Life Years
/
Lamivudine
/
Hepatitis B, Chronic
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Health economic evaluation
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2007
Type:
Article
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