Inhibitory Effect of SPA0355, a Thiourea Analogue, on Inflammation and Alveolar Bone Loss in Rats with Ligature-Induced Periodontitis
International Journal of Oral Biology
;
: 63-68, 2012.
Article
in Korean
| WPRIM
| ID: wpr-23059
ABSTRACT
It has been documented that SPA0355 exerts anti-inflammatory effects via the inhibition of nuclear factor-kappaB activation. In present study, we investigated the inhibitory effects of SPA0355 on periodontitis in an animal model. Periodontitis was induced by ligation of the cervix of the 1st molar in the left mandible in rats. After ligature, the rats were randomly divided into four groups and topically applied with SPA0355 (0.5, 1, and 2%) or the vehicle alone once daily for 10 days. Body weight and food intake were measured daily throughout the experimental period. At day 10 post-ligature, the infiltration of inflammatory cells and distance of the cementoenamel junction (CEJ) to the alveolar bone crest (ABC) in the distal area of ligatured tooth were estimated histopathologically. No changes in body weight or food intake were found between the control and SPA0355 groups. The degree of inflammation was decreased in all three SPA0355 application groups. A decrease CEJ-ABC distance was observed in the 0.5% and 1% SPA0355 groups. These results indicate that SPA0355 inhibits the infiltration of inflammatory cells and alveolar bone resorption and suggests its potential as a therapeutic agent for periodontitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontitis
/
Thiourea
/
Tooth
/
Body Weight
/
Bone Resorption
/
Cervix Uteri
/
Alveolar Bone Loss
/
Tooth Cervix
/
Models, Animal
/
Benzoxazines
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
International Journal of Oral Biology
Year:
2012
Type:
Article
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