Effects of endothelial cells on renewal and differentiation of neural stem cells / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1184-1186, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-230723
ABSTRACT
It is well established that neural stem cells (NSCs) are not randomly distributed throughout the brain, but rather are concentrated around blood vessels. Although NSCs lie in a vascular niche, there is no direct evidence for a functional relationship between the NSCs and blood vessel component cells. It is reported that endothelial cells release soluble factors that stimulate the self-renewal of NSCs, inhibit their differentiation, and enhance their neuron production. Endothelial coculture can activate Notch to promote self-renewal. Furthermore, vascular endothelial growth factor (VEGF) plays a significant role in neural cells; it stimulates the growth and differentiation of astrocytes in the central nervous system (CNS). Therefore, beyond their traditional role as structural components of blood vessels, endothelial cells are not only critical component of the neural stem cell niche, but they also are able to enhance neurogenesis, possibly through the secretion of brain-derived neurotrophic factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Stem Cells
/
Cell Differentiation
/
Cells, Cultured
/
Coculture Techniques
/
Brain-Derived Neurotrophic Factor
/
Bodily Secretions
/
Cell Biology
/
Endothelial Cells
/
Vascular Endothelial Growth Factor A
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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