G894T mutation of the endothelial nitric oxide synthase gene in Chinese Han nationality / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 415-426, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-231034
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality.</p><p><b>METHODS</b>G894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis.</p><p><b>RESULT</b>All subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05).</p><p><b>CONCLUSION</b>These results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Polymerase Chain Reaction
/
Nitric Oxide Synthase
/
Asian People
/
Nitric Oxide Synthase Type III
/
Ethnology
/
Genetics
/
Genotype
/
Mutation
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2003
Type:
Article
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