Study of levels of IL-18 and IFN-Gamma in serum of patients with condyloma acuminatum / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To study the role of interleukin(IL)18 and interferon gamma (IFN-Gamma) in the pathogenesis of condyloma acuminatum(CA).</p><p><b>METHODS</b>Double antibody sandwich ELISA was used to measure the levels of IL-18 and IFN-Gamma in serum of 30 cases of CA.</p><p><b>RESULT</b>The serum levels of IL-18 and IFN-Gamma of the CA patients were significantly higher than those of normal controls IL-18 132.00 +/-52.92 microg/L compared with 50.79 +/- 23.48 microg/L, P<0.01 IFN-Gamma80.83 +/-20.46 microg/L compared with 20.71 +/-11.18 microg/L P <0.01) and IL-18 levels were positively correlated with IFN-Gamma concentrations (r=0.754, t=6.081, P <0.01).</p><p><b>CONCLUSION</b>These data suggest that during infection of human papilloma viruses, anti-infective immune responses are activated.</p>