Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 279-291, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-231067
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of very late antigen(VLA) antagonist BIO-1211 on eosinophil chemotaxis, recruitment and mediator release.</p><p><b>METHODS</b>Eosinophil chemotaxis was induced by platelet activating factor(PAF) in vitro and eosinophil recruitment and release were determined in vivo.</p><p><b>RESULT</b>VLA antagonist BIO-1211 inhibited eosinophil chemotaxis induced by PAF. The inhibitory rates at 4x10(-11), 4x10(-10), 4x10(-9) mol x L(-1) were 24.9%, 29.9%, and 31.3%, respectively. Pretreatment by BIO-1211 1, 3 and 10 mg x kg(-1) intraperitoneally inhibited the recruitment of eosinophils in PAF in the rat induced by Sephadex in a dose dependent manner. Inhibitory rates were 60.3%, 68.9%, and 72.9%(P<0.05), respectively. BIO-1211 did not inhibit eosinophil peroxidase(EPO) release from eosinophils.</p><p><b>CONCLUSION</b>BIO-1211 inhibits eosinophil chemotaxis and recruitment, alleviates local inflammation, and may represent a new type of drug for allergic diseases.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligopeptides
/
Peroxidases
/
Pharmacology
/
Physiology
/
Platelet Activating Factor
/
Cell Movement
/
Chemotaxis, Leukocyte
/
Rats, Sprague-Dawley
/
Bodily Secretions
/
Integrin alpha4beta1
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2003
Type:
Article
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