Distribution of hepatitis B virus genotypes and serotypes in people who had a physical examination in Yunnan Province / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 114-116, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-231177
ABSTRACT
<p><b>OBJECTIVE</b>To know genotypes and serotypes of hepatitis B virus (HBV) detected from hepatitis B infected people in Yunnan Province.</p><p><b>METHODS</b>Serum samples were collected from HBsAg carriers detected from people who had a physical examination at Yunnan Provincial Center for Disease Control and Prevention. The S genes of HBV were amplified by nested PCR and the PCR products were sequenced. The viral genotype was identified by phylogenetic analysis. 27 reference sequences corresponding to HBV genotype A to I were obtained from GenBank. According to the amino acid sequences deduced from the nucleotide sequences of S gene, the dominant serotype of HBV detected from these people were confirmed.</p><p><b>RESULTS</b>39 HBsAg positive serum samples were detected from 2216 people who had a physical examination. The results shows that 76.9% were C genotype; 15.4% were B genotype; 5.1% were D genotype; 2.5% were I genotype. Three serotypes were found. The rates of adw2, adrq+ and ayr serotypes are 71.8%, 17.9% and 10.3% respectively. All of adw2 subtype specimens are C genotype. Among the serum specimens in which both HBsAg and HBeAg are positive, 75% were C genotype and adw2 subtype.</p><p><b>CONCLUSION</b>It is determined that the main genotype and subtype of HBV prevailed in Yunnan province is C genotype and adw2 subtype.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Examination
/
Virology
/
China
/
Hepatitis B virus
/
Population Surveillance
/
Classification
/
Allergy and Immunology
/
Genetics
/
Hepatitis B
/
Hepatitis B Surface Antigens
Type of study:
Screening study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2011
Type:
Article
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