Clinical application studies on AFP-L3 detected by micro-spin column method / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 461-463, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-231218
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical value of Lens culinaris agglutinin-reactive alpha-fetoprotein in the differentiation diagnosis between benign and malignant liver diseases, as well as the early warning of hepatocellular carcinoma.</p><p><b>METHODS</b>Alpha-fetoprotein variants from 300 patients with liver diseases were isolated with micro-spin column equipped lens culinaris agglutinin (LCA). The AFP and AFP-L3 were detected by the electrochemical luminescence (ECL) method, and the proportions of AFP-L3 were calculated.</p><p><b>RESULTS</b>The positive rates of AFP-L3 of HCC patients and chronic liver disease patients were 95% and 64% respectively, there were significant difference in two groups (chi2 = 134.72, P < 0.01), the HCC incidence rates of AFP-L3 positive and negative chronic liver disease patients showed significant difference (chi2 = 80.158, P < 0.01). there were no correlations between the proportion of AFP-L3 and AFP consistency(r = 0.046, P > 0.05).</p><p><b>CONCLUSIONS</b>The detection of AFP-L3 by micro-spin column assay show great clinical value in the differentiation diagnosis of benign and malignant liver diseases, as well as the early warning of hepatocellular carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Alpha-Fetoproteins
/
Biomarkers, Tumor
/
Chemistry
/
Carcinoma, Hepatocellular
/
Plant Lectins
/
Diagnosis
/
Diagnosis, Differential
/
Liver Diseases
/
Liver Neoplasms
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2010
Type:
Article
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