Analysis of thirteen cases with secondary coagulation disorder caused by raticide exposure / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 629-632, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-231276
ABSTRACT
<p><b>OBJECTIVE</b>To summarize the clinical characteristics of secondary coagulation disorders caused by exposure to poison (raticide) in children and to investigate the diagnosis and corresponding treatment.</p><p><b>METHOD</b>The process of diagnosis, clinical characteristics, response to treatment and the prognosis were analyzed.</p><p><b>RESULTS</b>The main clinical manifestation was mucosal bleeding (66.6%), including epistaxis, gingival bleeding, hematomas and so on. All these children were previously well and had no history of bleeding. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were prolonged, factor II was undetectable and the levels of factors VII, IX, and X were lower. The fibrinogen was normal. A raticide was detected in blood and urine of 13 children although 12 of the patients had no definite history of raticide ingestion. Prothrombin complex, fresh frozen plasma and vitamin K(1) were effective in these cases. However, 2 - 3 weeks later, 6 patients presented with recurrent bleeding.</p><p><b>CONCLUSION</b>For children with secondary coagulation disorders of unknown cause, intoxication of raticide should be considered. The administration of blood coagulation factors and vitamin K(1) are effective in early treatment, and the treatment period should be more than 2 months. The PT and APTT should be followed up. Vitamin K(1) should be stopped when PT and APTT are normal.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vitamin K 1
/
Poisoning
/
Rodenticides
/
Therapeutics
/
Blood Coagulation Disorders
/
Therapeutic Uses
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2010
Type:
Article
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