Lipase-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester in organic solvent / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 242-245, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-231341
ABSTRACT
A novel reaction-enzymatic ammonolysis discovered in the mid of 1990s has been demonstrated to be a very promising alternative in the preparation of optically pure compounds. The effects of organic solvent, initial water activity, temperature and additives on lipase Novozym435-catalyzed enantioselective ammonolysis of racemic phenylglycine methyl ester were investigated systematically in this paper. Enzymatic reaction of ammonolysis showed higher activity and enantioselectivity than the corresponding reaction of hydrolysis and alcoholysis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organic Chemicals
/
Pharmacology
/
Solvents
/
Surface-Active Agents
/
Temperature
/
Water
/
Catalysis
/
Dimethylformamide
/
Alcohols
/
Esters
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2002
Type:
Article
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