Research on the role of metabolism of fatty substance and osteoclast activity during the development of steroid-induced necrosis of femoral head / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 110-113, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-231478
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of metabolism of fatty substance and osteoclast activity during the process of steroid-induced necrosis of femoral head through mice model inducing and model index measurement.</p><p><b>METHODS</b>Forty SD male mice were divided into 2 groups randomly, the control group and the experiment group. After the gluteal injection of colibacillus endotoxin,the experiment group was given gluteal injection of prednisolone acetate 35.5 mg/kg per week, and 2 ml of normal saline to the control group. The mice were killed 12 weeks later and tested the content of Trap-5b, TC and TG of the blood serum. Vitodynamics, bone density were measured and sections of HE staining, Ca2+ and TRACP staining was made then statistic analysis was performanced.</p><p><b>RESULTS</b>The content of TC, TG and Trap-5b increased apparently (P < 0.01). Large amount of osteoclasts were found in local medullary cavity. There was severe bone loss and decrease of vitodynamics in subchondral bone (P < 0.01) in experiment group.</p><p><b>CONCLUSION</b>Metabolic disorder of fatty substance is the key pathogenesis of steroid-induced avascular necrosis of femoral head. Decrease of vitodynamics in subchondral bone due to hyperactivity and increase of osteoclast lead to collapse of femoral head directly.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Pharmacology
/
Steroids
/
Random Allocation
/
Bone Density
/
Rats, Sprague-Dawley
/
Disease Models, Animal
/
Fatty Acids
/
Femur Head Necrosis
/
Metabolism
Type of study:
Controlled clinical trial
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2009
Type:
Article
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