A prospective multicenter randomized double-blinded controlled clinical trial on effects of tiantai no.1 in treating mild cognitive impairment / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 255-258, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-231546
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical effectiveness and safety of Tiantai No. 1 (TT1) in treating mild cognitive impairment (MCI).</p><p><b>METHODS</b>With randomized double-blinded method adopted, the 128 MCI patients, selected according to the commonly accepted standard for MCI diagnosis, were assigned to 2 groups, the treatment group (65 cases) treated with TT1 and the control group (63 cases) treated with placebo for six months. Besides, a normal control group with 30 healthy elders was set up. Changes of comprehensive cognitive function, instant memory, short-term memory, calculation ability, orientating ability of time and space, language understanding ability as well as Chinese medicine syndromes before and after treatment were observed and compared.</p><p><b>RESULTS</b>The cognitive function of MCI patients was significantly lower than that of healthy elders (P<0.01). The comprehensive cognitive function, and all the above-mentioned abilities were significantly improved (P<0.05, P<0.01) in the TT1 treated group after treatment, with an effect significantly better than that in the placebo treated group (P<0.01). Overall evaluation of effect and safety suggested that the clinical effectiveness index (CEI) of TT1 was notably higher than that of the placebo. And it was found in one-year follow-up that the incidence of developing to Alzheimer's disease (AD) in the treatment group was strikingly lower than that in the control group (P<0.01).</p><p><b>CONCLUSION</b>TT1 can significantly improve the cognitive function of MCI patients, and reduce their incidence of developing to AD.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Double-Blind Method
/
Prospective Studies
/
Therapeutic Uses
/
Diagnosis
/
Drug Therapy
/
Cognitive Dysfunction
/
Medicine, Chinese Traditional
/
Phytotherapy
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Observational study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article
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