Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1465-1470, 2015.
Article
in English
| WPRIM
| ID: wpr-231753
ABSTRACT
<p><b>BACKGROUND</b>Hydrogen sulfide (H 2 S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H 2 S and conventional protein kinase CβII (cPKCβII) in CHD patients with uremic accelerated atherosclerosis (UAAS).</p><p><b>METHODS</b>A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H 2 S was measured with a sulfide sensitive electrode, and cPKCβII membrane translocation was detected by Western blotting.</p><p><b>RESULTS</b>Plasma H 2 S in CHD + AS group was significantly lower than that in CHD patients. cPKCβII membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H 2 S concentration was negatively correlated with cPKCβII membrane translocation in CHD + AS patients.</p><p><b>CONCLUSIONS</b>These findings suggest a possible linkage between H 2 S metabolism and cPKCβII activation, which may contribute to the development of UAAS in CHD patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Protein Kinase C
/
Blotting, Western
/
Renal Dialysis
/
Atherosclerosis
/
Hydrogen Sulfide
/
Metabolism
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2015
Type:
Article
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