Progress in the studies on antitumor natural product ecteinascidin-743 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 474-478, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-231904
ABSTRACT
The alkaloid ecteinascidin-743, isolated from the marine tunicate Ecteinascidia turbinata, binds to DNA and induces cytotoxic effects in several tumors. The drug is being codeveloped by Pharma Mar and Ortho Biotech. In May 2001 and October 2003, it was granted orphan drug status by the European Commission for soft tissue sarcoma and ovarian cancer, respectively. This paper reviews its research progress, including chemical synthesis, in vitro studies and mechanism of action, antitumor activity in vivo, toxicity, pharmacokinetics, and clinical studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pharmacokinetics
/
Antineoplastic Agents, Alkylating
/
Tetrahydroisoquinolines
/
Dioxoles
/
Toxicity
/
Isoquinolines
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS