Synthesis and antioxiactivity of squamosamide cyclic analogs / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 372-378, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-231925
ABSTRACT
<p><b>OBJECTIVE</b>To design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.</p><p><b>METHODS</b>Eleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.</p><p><b>RESULTS</b>Eleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.</p><p><b>CONCLUSION</b>Cyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenols
/
Chemistry
/
Annonaceae
/
Benzeneacetamides
/
Antioxidants
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2004
Type:
Article
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