Expression of apoptosis inhibitor gene Livin in prostate cancer and its clinical implication / 中华男科学杂志
National Journal of Andrology
;
(12): 30-33, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-231990
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of Livin, an apoptosis inhibitor gene, in prostate cancer, and to investigate its clinical and pathological implications.</p><p><b>METHODS</b>The expressions of Livin were detected in 62 cases of neoplastic prostate tissues and 10 cases of normal prostate tissues by RT-PCR and immunohistochemistry (SP method).</p><p><b>RESULTS</b>The Livin gene was highly expressed in neoplastic prostate tissues, but not in normal ones. Positive expression of Livin proteins was observed in 37 of the 62 (59.7%) tumor samples and accounted for 28.6%, 60.0% and 83.3% in the high, middle and low differentiation prostatic carcinoma groups respectively, with significant difference between the high and low groups. Livin positivity was also significantly correlated with tumor stages, increasing with tumor progression.</p><p><b>CONCLUSION</b>Livin may play an essential role in prostate carcinogenesis and serve as a marker for the prognosis of prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Prostatic Neoplasms
/
Immunohistochemistry
/
Gene Expression Regulation, Neoplastic
/
Disease Progression
/
Reverse Transcriptase Polymerase Chain Reaction
/
Adaptor Proteins, Signal Transducing
/
Inhibitor of Apoptosis Proteins
/
Genetics
Type of study:
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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