Nuclear status of day 2 preembryos affects embryo quality and implantation potential / 中华男科学杂志
National Journal of Andrology
;
(12): 26-29, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-231991
ABSTRACT
<p><b>OBJECTIVE</b>To assess the effects of the nuclear status of day 2 preembryos on day 3 embryo quality and implantation potential and to weigh its clinical value in the human in-vitro fertilization-embryo transfer (IVF-ET) program.</p><p><b>METHODS</b>Embryos obtained from 409 fresh conventional IVF-ET/ICSI cycles from July to October 2006 were assessed retrospectively. Day 2 preembryos were classified according to the number of nuclei in each blastomere in 3 groups grade A with only mononucleated blastomeres, grade B with one or more blastomeres containing no visible nucleus, and grade C with one or more multinucleated blastomeres. Comparisons were made of the rates of arrested embryos and excellent embryos on day 3 as well as of the pregnancy outcome and implantation potential of those in whom cohorts of similar nuclear scoring embryos were transferred.</p><p><b>RESULTS</b>There were fewer arrested embryos and more excellent embryos on day 3 in grade A than in grade B and C (P < 0.01), and so were there in grade B than in grade C (P < 0.01). Among the 234 cycles in which all the transfer embryos were derived from a similar day 2 nuclear scoring, 51 cycles originated from grade A embryos (group A) and 183 from grade B (group B), with similar clinical pregnancy rates between the two groups, while the implantation rate was higher in group A than in B (P < 0.05).</p><p><b>CONCLUSION</b>Day 2 nuclear scoring can be used to predict the devel- opment and implantation potential of embryos. A combined evaluation of day 2 nuclear scoring and day 3 embryo morphology helps identify the most viable embryos and reduce the number of embryos for transfer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Embryo Implantation
/
Physiology
/
Blastomeres
/
Pregnancy Outcome
/
Fertilization in Vitro
/
Cell Nucleus
/
Cleavage Stage, Ovum
/
Sperm Injections, Intracytoplasmic
/
Embryo Transfer
Type of study:
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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