Anti-apoptotic effect of the androgen receptor in human prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 1121-1124, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-231999
ABSTRACT
Prostate cancer is one of the common cancers in old men. Androgen ablation is a major option for the treatment of the metastatic diseases. However, most of the cancers progress to a more aggressive stage, so-called androgen-independent (or hormone refractory) relapse beyond any cure. The androgen receptor (AR) is an important factor in regulating the differentiation and proliferation of prostate epithelial cells, and also plays a critical role in cellular survival. Studies have demonstrated that aberrant activation of the AR is a major determinant in prostate cancer progression. We have provide a brief summary of AR-mediated cellular survival and an introduction to the advances of RNA interference techniques in silencing AR expression as a novel therapy for prostate cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Prostatic Neoplasms
/
Receptors, Androgen
/
Gene Expression Regulation, Neoplastic
/
Apoptosis
/
RNA Interference
/
Genetics
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2007
Type:
Article
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