Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome / 中华男科学杂志
National Journal of Andrology
;
(12): 1117-1120, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232000
ABSTRACT
Microdeletions of the Y chromosome are a most common known genetic cause of spermatogenetic failure in infertile men. Recent studies have revealed the existence of genetic factors in the long arm of the Y chromosome Yq11.23, known as azoospermia factors (AZF), which are further divided into three separate regions including AZFa, AZFb and AZFc. The AZF deletions are due to different recombination between large palindromic sequences during mesophase. Microdeletions of different AZF regions cause different degrees of spermatogenic impairment. The present paper reviews the clinical significance and relevant laboratory techniques of detecting AZF of the Y chromosome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sex Chromosome Aberrations
/
Chromosome Deletion
/
Seminal Plasma Proteins
/
Chromosomes, Human, Y
/
Diagnosis
/
Azoospermia
/
Genetic Loci
/
Genetics
/
Infertility, Male
Type of study:
Diagnostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2007
Type:
Article
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