Expression of prostate cancer antigen-1 in prostate cancer and its clinical significance / 中华男科学杂志
National Journal of Andrology
;
(12): 997-1001, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232024
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of prostate cancer antigen-1 (PCA-1) in different prostate tissues and analyze its correlation with the clinical parameters of prostate cancer (PCa).</p><p><b>METHODS</b>The expression of PCA-1 mRNA was detected by RT-PCR in the samples from 45 cases of PCa with various clinico-pathologic characteristics, 30 cases of high-grade prostatic intraepithelial neoplasia (HG-PIN), 43 cases of BPH and 39 cases of other carcinoma tissues. The correlation of PCA-1 mRNA expression with the clinical parameters of PCa was statistically analyzed and the PCA-1 expression was examined in different samples by immunohistochemistry.</p><p><b>RESULTS</b>The positive expression rate of PCA-1 mRNA was 88.9% and 60.0% and that of PCA-1 protein was 84.4% and 50.0% in the patients with PCa and HG-PIN, respectively. PCA-1 mRNA and PCA-1 proteins were not expressed in the BPH and other carcinoma tissues. The expression of PCA-1 mRNA was unrelated with the clinical parameters of PCa (P > 0.05).</p><p><b>CONCLUSION</b>It is suggested that PCA-1 is a PCa-specific gene and its expression is unrelated to the clinical parameters of PCa. It might serve as a specific biomarker for the early diagnosis of PCa.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
RNA, Messenger
/
Immunohistochemistry
/
Gene Expression Regulation, Neoplastic
/
Prostate-Specific Antigen
/
Reverse Transcriptase Polymerase Chain Reaction
/
Genetics
/
Metabolism
Type of study:
Screening study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2007
Type:
Article
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