Expression of coxsackie B virus-adenovirus receptor in prostate cancer Du145 and LNCaP cell lines and its significance / 中华男科学杂志
National Journal of Andrology
;
(12): 899-902, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232043
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of Coxsackie B virus-adenovirus receptor (CAR) in two prostate cancer cell lines with different metastatic potentials.</p><p><b>METHODS</b>The expressions of CAR in two prostate cancer cell lines (Du145 and LNCaP) with different metastatic potentials were detected by Western blotting. The Transwell polycarbonate filter was used to analyze the invasive potency.</p><p><b>RESULTS</b>As one of the adhesion associated proteins, CAR highly expressed in the LNCaP cell line, which is well known with a low metastatic potential, and lowly expressed in Du145 with a high metastatic potential (P < 0.01). The invasive potency of Du145 was significantly higher than that of LNCaP (P < 0.05).</p><p><b>CONCLUSION</b>There was a difference in the metastatic phenotypes of CAR among cell lines with different metastatic potentials. The expressions of CAR proteins may play an important role in repressing the metastasis of prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
Receptors, Virus
/
Blotting, Western
/
Cell Line, Tumor
/
Coxsackie and Adenovirus Receptor-Like Membrane Protein
/
Metabolism
/
Neoplasm Metastasis
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2007
Type:
Article
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