Immunogenetic analysis of human leukocyte antigen DRB1, DQB1 locus among Han ethnic children with Helicobacter pylori infection in Kunming / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 286-289, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-232089
ABSTRACT
<p><b>OBJECTIVE</b>To explore the immunogenetic features of human leukocyte antigen DRB1, DQB1 locus and children with Helicobacter pylori (H. pylori) infection in Han ethnic population in Kunming and its association with digestive diseases and H. pylori to better understand the immunogenetic features of the H. pylori infection.</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primer (PCR-SSP) method was used to study the HLA-DRB1, DQB1 allelic frequency distribution on 35 children with H. pylori infection and 37 healthy controls in Han ethnic population in Kunming.</p><p><b>RESULTS</b>Allelic frequencies of HLA-DRB1 * 0901, DQB1 * 03032 in the H. pylori infection group were lower than those of the healthy control group (7.14% vs. 31.08%, chi(2) = 13.16, Pc < 0.012; 5.71% vs. 25.68%, chi(2) = 10.68, Pc = 0.007) but the rest alleles' frequencies did not show significant differences.</p><p><b>CONCLUSION</b>These result suggested that HLA-DRB1 * 0901, DQB1 * 03032 might protect the H. pylori infection in Han ethnic population in Kunming.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
HLA-DQ Antigens
/
HLA-DR Antigens
/
China
/
Polymerase Chain Reaction
/
Epidemiology
/
Helicobacter pylori
/
Helicobacter Infections
/
Alleles
/
Allergy and Immunology
/
Ethnology
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2005
Type:
Article
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