Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 132-134, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-232119
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the relationship between circulating levels of insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 (IGFBP-3) and colorectal cancer.</p><p><b>METHODS</b>A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed.</p><p><b>RESULTS</b>The pooled odds ratio (OR) of IGF-1 and IGFBP-3 were 1.56 (95% CI 1.14-2.13) and 0.78 (95% CI 0.43-1.44) respectively. According to the results from different measurements (enzyme-linked immunoabsorbent assay and immunoradiometric assay), the pooled OR were 1.92 and 1.23 for IGF-1, 0.46 and 1.44 for IGFBP-3 respectively.</p><p><b>CONCLUSION</b>High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used, but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Insulin-Like Growth Factor I
/
Enzyme-Linked Immunosorbent Assay
/
Radioimmunoassay
/
Colorectal Neoplasms
/
China
/
Epidemiology
/
Risk Factors
/
Insulin-Like Growth Factor Binding Protein 3
/
Metabolism
Type of study:
Etiology study
/
Risk factors
/
Systematic reviews
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2005
Type:
Article
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