Study on the significance and application of crossover analysis in assessing gene-environmental interaction / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 54-57, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-232133
ABSTRACT
<p><b>OBJECTIVE</b>To examine the significance of crossover analysis in gene-environmental interaction studies.</p><p><b>METHODS</b>Through elaboration of a case-control study on the increased risk of venous thrombosis in oral-conceptive users who were carriers of factor V Leiden mutation, core information from 2 x 4 crossover table were analyzed and compared with stratified analysis and 'case only' study.</p><p><b>RESULTS</b>Different models (additive or multiplicative) in analyzing gene-environmental interaction yielded different results. The result of interaction based on multiplicative model was 1.35 (P > 0.05), compatible with that of stratified analysis and case only study. Calculated by crossover analysis based on additive model, synergy index S(S), attributable proportion of interaction (AP) and relative excess risk of interaction (RERI) appeared to be 3.90, 72.24%, 25.08 (P > 0.05) respectively.</p><p><b>CONCLUSION</b>Crossover analysis should further be applied in gene-environmental interaction studies.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Factor V
/
Genetic Markers
/
Case-Control Studies
/
Risk Factors
/
Cross-Over Studies
/
Contraceptives, Oral
/
Venous Thrombosis
/
Environment
/
Genetics
/
Genotype
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2005
Type:
Article
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