A study of interleukin-10 gene polymorphisms in Miao, Dong and Buyi ethnics of Guizhou / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 116-120, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-232191
ABSTRACT
<p><b>OBJECTIVE</b>To investigate allelic frequencies of interluekin-10 (IL-10) gene promoter in Miao, Dong and Buyi ethnics of Guizhou.</p><p><b>METHODS</b>TaqMan MGB-based real-time PCR was used to determine the genotypes of IL-10 -819 and IL-10 -592 in 589 Miao, Dong and Buyi ethnics of Guizhou.</p><p><b>RESULTS</b>The allelic frequency of IL-10 -819 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. Allelic frequencies of IL-10 -592 in Miao ethnics was significantly different from those in Dong or Buyi ethnics. In Miao, Dong and Buyi ethnics, the distributions of genotype frequencies of IL-10 -819 and IL-10 -592 were statistically different from Han ethnics from Guizhou and Taiwan of China as well as South Koreans.</p><p><b>CONCLUSION</b>There is a heterogeneity in the frequencies of polymorphisms of IL-10 promoter among different ethnic groups.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Promoter Regions, Genetic
/
Interleukin-10
/
Polymorphism, Single Nucleotide
/
Population Groups
/
Asian People
/
Alleles
/
Ethnology
/
Gene Frequency
/
Genetics
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2013
Type:
Article
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