Lung cancer and its epigenetics association with chronic obstructive pulmonary disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 70-73, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-232202
ABSTRACT
Lung cancer and chronic obstructive pulmonary disease (COPD) are the leading causes of morbidity and mortality worldwide. Development of lung cancer involves both genetic and environment factors. In addition to genetic alterations, epigenetic mechanism is closely involved in pathogenesis of lung cancer. Characterized by an abnormal persistent inflammatory response to noxious environmental stimulation, COPD has shown to increase the susceptibility for lung tumorigenesis in previous research. Current research on epigenetics of lung cancer and COPD has focused on aberrant DNA methylation, histone acetylation and non-coding RNAs regulation. The aberrant DNA methylation associated with lung cancer and COPD has included overexpression of DNA methyltransferase, global DNA hypomethylation and DNA hypermethylation in promoter regions, while histone acetylation and histone methylation are the major changes for histone modification, in which histone acetyltransferases, histone deacetylases, histone methyltransferases and histone demethylases play the most important roles. RNA interference and microRNAs are both hot topics of research on non-coding RNAs regulation. Understanding of concurrent epigenetic alterations in the pathogenesis of lung cancer and COPD may facilitate identification of specific therapeutic targets and development of effective treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acetylation
/
Histones
/
DNA Methylation
/
RNA, Untranslated
/
Pulmonary Disease, Chronic Obstructive
/
Epigenesis, Genetic
/
Genetics
/
Lung Neoplasms
/
Metabolism
/
Methylation
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2013
Type:
Article
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