Association between ESR1 gene polymorphisms and haplotypes with schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 21-25, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-232213
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between single nucleotide polymorphisms (SNPs) and haplotypes of estrogen receptor 1 (ESR1) gene with schizophrenia.</p><p><b>METHODS</b>Three SNPs (rs2234693, rs9340799 and rs3798759) were determined in 333 schizophrenic patients and 315 healthy subjects with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Allelic and genotypic frequencies and particular haplotypes were compared between the two groups using Chi-square test.</p><p><b>RESULTS</b>The allelic and genotypic frequencies of rs2234693 and rs9340799 showed no significant difference between the two groups (P U+003E 0.05). However, a significant difference was detected in the frequencies of rs3798759 G allele and GG genotype between the two groups (P U+003C 0.01). Single factor analysis stratified by sex also found that frequencies of rs3798759 GG and TG genotypes and G allele were significantly higher in female schizophrenia patients compared with healthy females (P U+003C 0.05). Haplotypes C-A-G and C-G-G were more common in schizophrenia group (P U+003C 0.05).</p><p><b>CONCLUSION</b>polymorphisms of rs3798759 may be a risk factor for female patients with schizophrenia, and haplotypes C-A-G and C-G-G may be risk factors for schizophrenia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Haplotypes
/
Base Sequence
/
Case-Control Studies
/
Sex Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Estrogen Receptor alpha
/
Alleles
/
Gene Frequency
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2013
Type:
Article
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