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A population genetic study of 22 autosomal loci of single nucleotide polymorphisms / 中华医学遗传学杂志
Article in Chinese | WPRIM | ID: wpr-232223
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate polymorphisms and forensic efficiency of 22 non-binary single nucleotide polymorphism (SNP) loci.</p><p><b>METHODS</b>One hundred ethnic Han Chinese individuals were recruited from Dongguan, Guangdong. The 22 loci were genotyped with matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS).</p><p><b>RESULTS</b>Nine loci were found with a single allele, 4 loci were found to be biallelic, whilst 9 loci were found to have 3 alleles. For 13 polymorphic loci, the combined discrimination power and power of exclusion were 0.999 98 and 0.9330, respectively. For the 9 non-biallelic loci, the combined discrimination power and power of exclusion were 0.9998 and 0.8956, respectively. For motherless cases, the combined power of exclusion was 0.6405 for 13 polymorphic SNPs and 0.6405 for 9 non-binary SNPs.</p><p><b>CONCLUSION</b>Non-binary loci have a greater discrimination power and exclusion power per SNP.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Male / China / Polymorphism, Single Nucleotide / Genetic Load / Asians / Alleles / Gene Frequency / Genetics Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Female / Humans / Male / China / Polymorphism, Single Nucleotide / Genetic Load / Asians / Alleles / Gene Frequency / Genetics Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article