Establishment of median values for second trimester maternal serum biomarkers in Weihai region / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 693-696, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-232229
ABSTRACT
<p><b>OBJECTIVE</b>To establish the median values for second trimester biomarkers in Weihai region, and to assess its value for improving the performance and efficiency of prenatal screening.</p><p><b>METHODS</b>Maternal serum alpha-fetoprotein (AFP) and free beta human chorionic gonadotropin (Free beta-hCG) were determined for 24 400 pregnant women at 105 to 146 gestational days. A regression equation was derived after adjusting for different gestational ages. The median values were further adjusted with body weight.</p><p><b>RESULTS</b>The median values of AFP and Free beta-hCG were respectively 6% and 24% higher than those embedded in a 2T software. After adjusting with gestational age and weight, there is a significant difference in multiple of the median (MoM) of serum biomarkers between local population and that embedded in the 2T model.</p><p><b>CONCLUSION</b>To establish the median values for different gestational ages for local region may help to improve the efficiency of prenatal screening.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Trimester, Second
/
Reference Values
/
Blood
/
Pregnancy Outcome
/
Biomarkers
/
Chorionic Gonadotropin, beta Subunit, Human
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2012
Type:
Article
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