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Association study of NOS1 gene polymorphisms and schizophrenia / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 459-463, 2012.
Article in Chinese | WPRIM | ID: wpr-232275
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association between nitric oxide synthase 1 (NOS1) gene polymorphisms and schizophrenia.</p><p><b>METHODS</b>Twenty eight tag single nucleotide polymorphisms (SNPs) of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay.</p><p><b>RESULTS</b>One SNP (rs1520811) was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction (P>0.05). Further analysis has failed to identify any association between particular haplotypes and the disease.</p><p><b>CONCLUSION</b>Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Haplotypes / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Nitric Oxide Synthase Type I / Genetics Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Haplotypes / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Nitric Oxide Synthase Type I / Genetics Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article