Study on the association between STK15 Phe31Ile polymorphisms and esophageal squamous cell carcinoma / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 394-397, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232294
ABSTRACT
<p><b>OBJECTIVE</b>To study the relation between single nucleotide polymorphism(SNP) at the 91T-->A(Phe31Ile) position of the STK15 gene and the susceptibility of esophageal squamous cell carcinoma (ESCC) in She county--a ESCC high incidence region in North China.</p><p><b>METHODS</b>Polymerase-chain reaction(PCR)-restriction fragment length polymorphism (RFLP) analysis was used to detect the genotypes of STKl5 Phe31Ile(91T-->A) SNP, and the samples came from 296 ESCC patients and 302 healthy controls.</p><p><b>RESULTS</b>The risk of ESCC significantly increased in the group which had been smoking or having a family history of upper gastrointestinal cancer (UGIC) (the OR = 1.68 and 1.77, 95% CI 1.34-2.10 and 1.44-2.19, respectively). Rates of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of the STK15 Phe31Ile (91T-->A) SNPs in ESCC patients were 11.5%, 34.8% and 53.7%, respectively, and were not significantly different from that in the healthy group (11.9%, 36.8% and 51.3%) (chi2 = 0.35, P = 0.84). When compared to Phe/Phe genotype, Phe/Ile and Ile/Ile of STK15 91T-->A(Phe31Ile)did not show effect on the risk of ESCC according to the odds ratio results which were 0.98 (95% CI 0.57-1.69) and 1.09 (0.65-1.82) respectively. STK15 91T-->A (Phe31Ile) SNP also did not significantly influence on the development of ESCC even the samples were stratified by sex, smoking status and family history of upper gastrointestinal cancer.</p><p><b>CONCLUSION</b>The STK15 Phe31Ile(91T-->A) polymorphisms seemed irrelevant with the risk of ESCC in She county.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Case-Control Studies
/
Protein Serine-Threonine Kinases
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Aurora Kinases
/
Aurora Kinase A
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
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