Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 136-140, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232335
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.</p><p><b>METHODS</b>LEPR G1n223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay.</p><p><b>RESULTS</b>In univariate regression analyses, we found serum level of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P < 0.05-0.001, respectively). Through multivariable analyses, we found that increased risk estimates for breast cancer were among those with leptin level (OR = 1.53, 95% CI 1.13-2.07, P = 0.006), LEPR Gin223Arg genotype (OR = 4.87, 95%CI1.30-18.22, P = 0.019), WHR (OR = 3.68, 95% CI 1.34-10.11, P = 0.011).</p><p><b>CONCLUSION</b>Results from this study suggested that LEPR Gln233Agr polymorphism, the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Blood
/
Breast Neoplasms
/
Enzyme-Linked Immunosorbent Assay
/
Risk
/
Genetic Predisposition to Disease
/
Leptin
/
Receptors, Leptin
/
Genetics
/
Lipids
Type of study:
Etiology study
/
Risk factors
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
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