Clinical characteristies and distribution of hepatitis B virus genotype and sub-genotype / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 74-77, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-232377
ABSTRACT
<p><b>OBJECTIVE</b>To determine the distribution and virologic characteristics of HBV genotypes, sub-type and possible association with the severity of liver disease.</p><p><b>METHODS</b>884 patients infected with HBV were enrolled from 8 provinces in China. HBV genotype and sub-type was determined, using PCR-RFLP method.</p><p><b>RESULTS</b>The most common HBV genotypes were B (20.77% ) and C (78.22 % ) but only 1 patient showed genotypes D. We found sub-type Ba in patients with genotype B, C1 and C2 sub-type in patients with genotype C. Genotype C (83.62%) and sub-type C2 (90.32%) were predominant in northern China. Patients with genotype B were much younger than those with genotype C. There was no significant difference between patients with sub-type C1 and C2. There was no significant difference in liver function and serum HBV-DNA load between patients with genotype B and C,or between patients with sub type C1 and C2. However, hepatic inflammation and fibrosis score in patients with genotype B were significantly lower than those with genotype C.</p><p><b>CONCLUSION</b>There were no significantly differences in liver function and HBV-DNA load between patients with genotype B and C, or between patients with sub-type C1 and C2. Hepatic inflammation and fibrosis score in patients with genotype B were significantly lower than those with genotype C. Genotype C/sub-type C2 were preponderance in northern China.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virology
/
Molecular Sequence Data
/
China
/
Hepatitis B virus
/
Classification
/
Viral Load
/
Allergy and Immunology
/
Genetics
/
Genotype
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
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