Anesthetic effects of repeated dosing with propofol and vitamin C in mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1701-1704, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-232543
ABSTRACT
<p><b>OBJECTIVE</b>To explore the anesthetic effects of repeated administration of propofol combined with vitamin C in mice.</p><p><b>METHODS</b>Forty mice were subjected to daily intraperitoneal injections of 80 mg/kg propofol (P80 group), 70 mg/kg propofol and 50 mg/kg vitamin C (P70+Vc50 group), 55 mg/kg propofol and 100 mg/kg vitamin C (P55+Vc100 group), or 50 mg/kg propofol and 200 mg/kg vitamin C (P50+Vc200 group) for 6 consecutive days, and the anesthesia induction time and anesthesia duration were recorded.</p><p><b>RESULTS</b>Compared with the P80 group, the mice in P55 + Vc100 group and P50 + Vc200 group showed significantly shorter anesthesia duration on the first 3 days (P<0.05). In all the groups, anesthesia duration was significantly shortened in the following days compared with that on day 1 (P<0.01); anesthesia duration was shorter on day 3 than on day 2 in P50 + Vc200 group (P<0.01), and was shorter on days 4, 5, and 6 than on day 2 in all the groups (P<0.01). In all the groups, the rate of loss of righting reflex (LORR) decreased gradually with time in a similar pattern.</p><p><b>CONCLUSION</b>Vitamin C can reduce the dose of propofol without obviously affecting the anesthetic effect to reduce the incidence of drug tolerance and potential dose-related side effects of propofol.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Ascorbic Acid
/
Anesthesia Recovery Period
/
Propofol
/
Anesthetics, Intravenous
/
Drug Tolerance
/
Anesthesia
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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