Folate receptor-mediated antitumor drugs / 药学学报
Acta Pharmaceutica Sinica
;
(12): 109-114, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-232588
ABSTRACT
Folate receptor (FR) is over-expressed in a variety of human cancers and it is seldom expressed or found in normal tissues. Therefore, folate receptor-mediated antitumor drugs can be targeted specially to the FR-positive tumor cells. This strategy improves the selectivity of drugs which may destroy the normal tissues in traditional chemotherapeutics. This review provides the delivery mechanism of FR-mediated antitumor drugs and highlights the novel folate-drug conjugates and their activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Drug Carriers
/
Carrier Proteins
/
Chemistry
/
Drug Delivery Systems
/
Receptors, Cell Surface
/
Cell Line, Tumor
/
Folate Receptors, GPI-Anchored
/
Folic Acid
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Type:
Article
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