The action of TSG101 on HIV-1 budding and related inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1165-1170, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232623
ABSTRACT
tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Transcription Factors
/
Virus Replication
/
Drug Design
/
Chemistry
/
HIV-1
/
Anti-HIV Agents
/
DNA-Binding Proteins
/
Gag Gene Products, Human Immunodeficiency Virus
Type of study:
Prognostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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