Effects of beta-lactam antibiotics on development of tolerance and dependence to morphine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1094-1098, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232637
ABSTRACT
In order to identify ceftriaxone and its analogs whether has the function of anti-tolerance of morphine and study the dose-effect relation of ceftriaxone in mice, hot plate method to measure pain threshold of mouse and naloxone withdrawal models were carried out and compared with normal saline group. Ceftriaxone and cefotaxime had the effect of anti-tolerance and anti-dependence of morphine notably. And ceftriaxone has the effect of anti-tolerance of morphine in a dose dependent manner.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Substance Withdrawal Syndrome
/
Ceftriaxone
/
Random Allocation
/
Cefotaxime
/
Pain Threshold
/
Dose-Response Relationship, Drug
/
Drug Tolerance
/
Anti-Bacterial Agents
/
Morphine
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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