Advances in the chemical and biological studies of polyamides / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1089-1093, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232638
ABSTRACT
Polyamides, containing N-methylpyrrole (Py) and N-methyl-imidazole (Im) amino acids, are synthetic oligomers programmed to read the DNA double helix in the minor groove with high affinities and sequence specificities resulting in modulation of gene expression. They are cell permeable, stable and have no cytotoxicity, which provide a promising tool of gene regulation. We describe here recent advances in the field of DNA binding polyamides, including pairing rules, specifities and affinities to DNA, synthesis methods, cellular and nuclear uptake properties, gene regulation and effectiveness in vivo. The potential problems and difficulties in future research are also discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pyrroles
/
DNA
/
Chemistry
/
Gene Expression Regulation
/
DNA Footprinting
/
Base Pairing
/
Genetics
/
Imidazoles
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS