Progress in the new nonnucleoside anti-HIV reverse transcriptase inhibitor-DCK / 药学学报
Acta Pharmaceutica Sinica
;
(12): 997-1002, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232653
ABSTRACT
3',4'-Di-O-(S)-comphanoyl-(+)-cis-khellactone (DCK) is a synthetic khellactone ester that exhibits potent anti-HIV activity with a mechanism distinct from clinically used anti-HIV agents. Several series of DCK analoges have been synthesized and evaluated for inhibitory effects against HIV. This review article describes recent progress in the discovery, structural modification, and structure-activity relationship studies of potent anti-HIV DCK derivatives.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Camphor
/
Biological Availability
/
Chemistry
/
HIV
/
Anti-HIV Agents
/
Coumarins
/
HIV Reverse Transcriptase
/
Lactones
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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