Progress in the studies on small molecule IGF-1R inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 979-984, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232656
ABSTRACT
The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Piperazines
/
Pyridones
/
Pyrimidines
/
Pyrroles
/
Benzimidazoles
/
Signal Transduction
/
Catechin
/
Chemistry
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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