Characterization of microstructure of ibuprofen-hydroxypropyl-beta-cyclodextrin and ibuprofen-beta-cyclodextrin by atomic force microscope / 药学学报
Acta Pharmaceutica Sinica
;
(12): 969-973, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232658
ABSTRACT
The microstructures of ibuprofen-hydroxypropyl-bets-cyclodextrin (IBU-HP-beta-CyD) and ibuprofen-beta-cyclodextrin (IBU-beta-CyD) were observed by atomic force microscope (AFM). The high resolving capability of AFM has the tungsten filament probe with the spring constant of 0.06 N x m(-1). Samples were observed in a small scale scanning area of 10.5 nm x 10.5 nm and 800 x 800 pixels. The original scanning images were gained by tapping mode at room temperature. Their three-dimensional reconstruction of microstructure was performed by G3DR software. The outer diameters of HP-beta-CyD and beta-CyD are 1.53 nm. The benzene diameter of IBU is 0.62 nm, fitting to the inner diameters of HP-beta-CyD and beta-CyD. The benzene and hydrophobic chain of IBU enter into the hole of cyclodextrin at 11 ratio. The results were evidenced by IR, X-ray diffraction and the phase solubility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spectrophotometry, Infrared
/
X-Ray Diffraction
/
Chemistry
/
Ibuprofen
/
Drug Delivery Systems
/
Microscopy, Atomic Force
/
Analgesics, Non-Narcotic
/
Beta-Cyclodextrins
/
2-Hydroxypropyl-beta-cyclodextrin
/
Methods
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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