Synthesis and antinociceptive activity of seselin derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 930-933, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232666
ABSTRACT
Natural product seselin and related derivatives with an angular pyranocoumarin skeleton were synthesized from 8-acetyl-7-hydroxycoumarins by condensation with acetone, reduction, and dehydration successively under mild conditions with total yield of > 50%. Twelve seselin derivatives were tested by the writhing response assay induced by acetic acid at a dose of 40 mg x kg(-1). Seselin (4a) and 4,8,8-trimethyl-9,9-dihydro-pyran[2,3-f] chromene-2,10-dione (2b) showed obviously antinociceptive activity with inhibitory effect of 85% and 50%, respectively, more or quite potent than aspirin in the same assay, suggesting that seselin derivatives could be a novel kind of potential antinociceptive agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pain Measurement
/
Molecular Structure
/
Chemistry
/
Chromones
/
Coumarins
/
Analgesics
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS