Synthesis and antiinflammation activity of aromatic aminoketone compounds, a new type of PAF-receptor antagonist / 药学学报
Acta Pharmaceutica Sinica
;
(12): 917-925, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-232668
ABSTRACT
A series of aromatic aminoketones were synthesized by Mannich reaction. Structures of these compounds were confirmed by 1H NMR, MS and HRMS or element analysis. Pharmacological screening showed that most target compounds inhibited the release of beta-glucuronidase in polymorphonuclear leucocytes by PAF (platelet activating factor) and compounds MA12, MA13, MA18, MA21 and MA33 were more active. The study suggests that target compounds are potential PAF receptor antagonists and their anti-inflammatory activities are due to the inhibition of release of lysosomal enzyme.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Arthritis, Rheumatoid
/
Structure-Activity Relationship
/
Platelet Membrane Glycoproteins
/
Chemistry
/
Tumor Necrosis Factor-alpha
/
Macrophages, Peritoneal
/
Receptors, G-Protein-Coupled
/
Therapeutic Uses
/
Drug Therapy
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2008
Type:
Article
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